June 21, 1968 at Cleveland Stadium
Indians 4, Tigers 3 (43-24)
The Tigers blew a thirteenth inning lead as they dropped their series opener to the Indians. Jim Northrup had doubled home Mickey Stanley in the top of the thirteenth inning but Pat Dobson gave up a two run homer in the bottom of the inning and he fell to 2-1. This was after a solid start by Mickey Lolich, who gave up two runs on six hits with three strikeouts in nine innings.
The Tigers picked up seven hits and they were all by different hitters. Norm Cash drew three walks while Dick McAuliffe doubled, drove in a run and drew a walk.